The forerunner to hyperthermia is fever therapy. Coley, Issels, and others have found active fever therapy particularly effective in cancer treatment; we have experienced the same.
It breaks through reaction blockades, speeds up the elimination of toxins from the body, and especially, stimulates the immune system in general. Unlike passive hyperthermia where the body or the tumor is heated from the outside by appropriate devices, active fever therapy induces a fever up to and above 40°C by intravenous administration of bacterial lipopolysaccharides. The sole purpose of active fever therapy is not so much a matter of killing tumor cells. To achieve this, temperatures of around 43°C (109.4 Fahrenheit) would have to be generated in the cancerous tissue which, of course, is humanly unfeasible. However, the advantage of active fever therapy comes from the changes in the cell that makes supplemental therapies much more effective.